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ID: ALA1132661
Journal: Bioorg Med Chem Lett
Title: Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.
Authors: Pevarello P, Traquandi G, Bonsignori A, McArthur RA, Maj R, Caccia C, Salvati P, Varasi M.
Abstract: Dextromethorphan 1 is an effective neuroprotectant in animal models of epilepsy and ischemia but showed side-effects during clinical trials limiting its potential use in a clinical setting. Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed alpha-amino amide anticonvulsant (3).
CiteXplore: 10406642