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ID: ALA1132662
Journal: Bioorg Med Chem Lett
Title: Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping.
Authors: Brouillette WJ, Atigadda VR, Luo M, Air GM, Babu YS, Bantia S.
Abstract: A 2-pyrrolidinone ring containing a single hydroxymethyl side chain effectively replaces the N-acetylamino group of 4-(N-acetylamino)-3-guanidinobenzoic acid, a low micromolar inhibitor of influenza neuraminidase. This novel structural template affords new opportunities to evolve more potent benzoic acid inhibitors.
CiteXplore: 10450950