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ID: ALA1132664
Journal: Bioorg Med Chem Lett
Title: C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Authors: Goulet MT, Sinclair PJ, Wong F, Staruch MJ, Dumont FJ, Cryan JG, Wiederrecht GJ, Wyvratt MJ, Parsons WH.
Abstract: A tether length study of C32-O-phenalkyl ether derivatives of ascomycin was conducted wherein it was determined that a 2-carbon tether provides optimum in vitro immunosuppressive activity. Oxygen-bearing substituents along the 2-carbon tether can further increase the potency of this design.
CiteXplore: 10450986