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ID: ALA1132668
Journal: Bioorg Med Chem Lett
Title: The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.
Authors: Cody WL, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, St-Denis Y, Winocour PD, Siddiqui MA.
Abstract: Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described.
CiteXplore: 10498196