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ID: ALA1132727
Journal: Bioorg Med Chem Lett
Title: A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.
Authors: Tsubaki K, Taniguchi K, Tabuchi S, Okitsu O, Hattori K, Seki J, Sakane K, Tanaka H.
Abstract: A novel optically pure pyridazinone derivative was synthesized and identified as a nonprostanoid PGI2 agonist. It inhibited ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.
CiteXplore: 11133092