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ID: ALA1132735
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides.
Authors: Luo MZ, Liu MC, Mozdziesz DE, Lin TS, Dutschman GE, Gullen EA, Cheng YC, Sartorelli AC.
Abstract: Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against HBV, whereas the D-configuration analogue (14) has been found to exhibit potent anti-HIV activity.
CiteXplore: 10999490