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ID: ALA1132741

Journal: Bioorg Med Chem Lett

Title: Novel antifungals based on 4-substituted imidazole: a combinatorial chemistry approach to lead discovery and optimization.

Authors: Saha AK, Liu L, Simoneaux RL, Kukla MJ, Marichal P, Odds F.

Abstract: A series of 4-substituted imidazole sulfonamides has been prepared by solid-phase chemistry. These compounds were found to have good in vitro antifungal activity and constitute the first examples of C-linked azoles with such activity. The most potent inhibitor (30) demonstrated inhibition of key Candida strains at an in vitro concentration of < 100nM and compared favorably with in vitro potency of itraconazole.

CiteXplore: 11012023

DOI: 10.1016/s0960-894x(00)00445-5