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ID: ALA1132742

Journal: Bioorg Med Chem Lett

Title: The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.

Authors: Grant EB, Guiadeen D, Baum EZ, Foleno BD, Jin H, Montenegro DA, Nelson EA, Bush K, Hlasta DJ.

Abstract: Beta-lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse beta-lactamases, especially those in molecular classes A and C. A structure activity relationship (SAR) study of a high-throughput screening lead resulted in the discovery of a potent and selective non-beta-lactam inhibitor of class C beta-lactamases.

CiteXplore: 11012024

DOI: 10.1016/s0960-894x(00)00444-3