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ID: ALA1132759
Journal: Bioorg Med Chem Lett
Title: The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.
Authors: Maitrejean M, Comte G, Barron D, El Kirat K, Conseil G, Di Pietro A.
Abstract: A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested.
CiteXplore: 10673101