Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

ID: ALA1132767

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists.

Authors: Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE.

Abstract: Identification of a number of highly potent M2 receptor antagonists with >100-fold selectivity against the M1 and M3 receptor subtypes is described. In the rat microdialysis assay, this series of compounds showed pronounced enhancement of brain acetylcholine release after oral administration.

CiteXplore: 11055330

DOI: 10.1016/s0960-894x(00)00457-1

Patent ID: ┄