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ID: ALA1132785
Journal: Bioorg Med Chem Lett
Title: Optimising inhibitors of trypanothione reductase using solid-phase chemistry.
Authors: Chitkul B, Bradley M.
Abstract: A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a Ki of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature.
CiteXplore: 11055357