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ID: ALA1132786
Journal: Bioorg Med Chem Lett
Title: Chemical modification of nodulisporic acid A: preliminary structure-activity relationships.
Authors: Meinke PT, Ayer MB, Colletti SL, Li C, Lim J, Ok D, Salva S, Schmatz DM, Shih TL, Shoop WL, Warmke LM, Wyvratt MJ, Zakson-Aiken M, Fisher MH.
Abstract: Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermissive' regions and led to the discovery of new nodulisporamides with significantly improved flea efficacy.
CiteXplore: 11055358