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ID: ALA1132791
Journal: Bioorg Med Chem Lett
Title: 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.
Authors: Aoyama Y, Uenaka M, Konoike T, Iso Y, Nishitani Y, Kanda A, Naya N, Nakajima M.
Abstract: 1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure-activity relationship studies of 1-oxacephems led to compounds 15, which exhibited 27 nM inhibition of human chymase and improvement of stability in human plasma (t 1/2 1.5 h).
CiteXplore: 11078188