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ID: ALA1132799
Journal: Bioorg Med Chem Lett
Title: Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer.
Authors: Kitajima H, Nakamura M, Tamakawa H, Goto N.
Abstract: Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity.
CiteXplore: 11078199