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ID: ALA1132802
Journal: Bioorg Med Chem Lett
Title: Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
Authors: Rajendran V, Prakash KR, Ved HS, Saxena A, Doctor BP, Kozikowski AP.
Abstract: (+/-)-10,10-Dimethylhuperzine A (2, DMHA) has been synthesized, and its enantiomers have been separated using chiral HPLC. (-)-DMHA inhibits AChE with a Ki value approaching that of (-)-huperzine A, whereas (+)-DMHA shows no AChE inhibitory activity. On the other hand, both enantiomers are equally potent against glutamate-induced neurotoxicity when tested in neurons.
CiteXplore: 11078202