Parallel synthesis of isatin-based serine protease inhibitors.

ID: ALA1132805

Journal: Bioorg Med Chem Lett

Title: Parallel synthesis of isatin-based serine protease inhibitors.

Authors: Shuttleworth SJ, Nasturica D, Gervais C, Siddiqui MA, Rando RF, Lee N.

Abstract: The synthesis of N-functionalised isatins using parallel, solution synthesis is described. Functionalised polymers were employed as stoichiometric and catalytic reagents as well as purification media in the exercise, and the derivatives were screened against a panel of serine proteases; high percentage inhibition was observed in several cases.

CiteXplore: 11086715

DOI: 10.1016/s0960-894x(00)00523-0

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