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ID: ALA1132812
Journal: Bioorg Med Chem Lett
Title: Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid.
Authors: Kehler L, Hansen HI, Sanchez C.
Abstract: 1-Propylbutylphosphinic acid 2, (1-propylbutyl)methylphosphinic acid 3 and 1-propylbutylphosphonic acid 4 have been synthesized as bioisosteres of the corresponding carboxylic acid valproate 1, which is a potent anticonvulsant. The novel phosphinic and phosphonic acids were tested for their anticonvulsant activity and were found to be inactive.
CiteXplore: 11086726