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ID: ALA1132851
Journal: Bioorg Med Chem Lett
Title: Synthesis of the repeating unit of the O-specific polysaccharide of Shigella sonnei and quantitation of its serologic activity.
Authors: Tóth A, Medgyes A, Bajza I, Lipták A, Batta G, Kontrohr T, Péterffy K, Pozsgay V.
Abstract: The chemical synthesis of the zwitterionic disaccharide 2 is described that corresponds to the repeating unit of the O-specific polysaccharide (1) of the gram-negative human pathogen Shigella sonnei. Passive hemolysis inhibition tests using a hyperimmune rabbit serum raised against S. sonnei showed that the serologic activity of the disaccharide 2 is nearly 2- to 3-fold higher than those of its component monosaccharides. NMR data of 2 are in support of the proposed structure of the O-specific polysaccharide.
CiteXplore: 10636234