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ID: ALA1132855

Journal: Bioorg Med Chem Lett

Title: Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Authors: Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP.

Abstract: Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.

CiteXplore: 10636230

DOI: 10.1016/s0960-894x(99)00584-3