Synthesis and binding studies of some epibatidine analogues.

ID: ALA1132857

Journal: Bioorg Med Chem Lett

Title: Synthesis and binding studies of some epibatidine analogues.

Authors: Rádl S, Hezký P, Hafner W, Budesínský M, Hejnová L.

Abstract: A series of epibatidine analogues and their positional isomers bearing an 8-azabicyclo[3.2.1]octane moiety is described. Some of the compounds, especially those containing 8-azabicyclo[3.2.1]oct-2-ene moiety show high affinity for the nicotinic cholinergic receptor.

CiteXplore: 10636243

DOI: 10.1016/s0960-894x(99)00575-2

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