A rationally designed anticancer drug targeting a unique binding cavity of tubulin.
Basic Information
ID: ALA1132867
Journal: Bioorg Med Chem Lett
Title: A rationally designed anticancer drug targeting a unique binding cavity of tubulin.
Authors: Uckun FM, Mao C, Vassilev AO, Navara CS, Narla RK, Jan ST.
Abstract: A novel mono-THF containing synthetic anticancer drug (WHI-261) was designed for targeting a previously unrecognized unique narrow binding cavity on the surface of tubulin. The anti-cancer activity of WHI-261 was confirmed using MTT assays. The structure-based design, synthesis, and biological activity of WHI-261 are reported.
CiteXplore: 10843205
DOI: 10.1016/s0960-894x(00)00148-7
Patent ID: ┄
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