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ID: ALA1132870
Journal: Bioorg Med Chem Lett
Title: Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors.
Authors: Gong Y, Becker M, Choi-Sledeski YM, Davis RS, Salvino JM, Chu V, Brown KD, Pauls HW.
Abstract: A focused library (4 x 14) prepared from 4-aminopyridine and 4-, 5-, and 6-azoindole templates was synthesized using 14 polymer supported 4-amido-2,3,5,6-tetrafluorophenyl (TFP) sulfonate esters inputs. Several compounds were identified as factor Xa inhibitors (IC50< or =0.1 microM) helping to establish the SAR among these four series of azarene pyrrolidinones.
CiteXplore: 10843210