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ID: ALA1132875
Journal: Bioorg Med Chem Lett
Title: Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.
Authors: Coburn CA, Rush DM, Williams PD, Homnick C, Lyle EA, Lewis SD, Lucas BJ, Di Muzio-Mower JM, Juliano M, Krueger JA, Vastag K, Chen IW, Vacca JP.
Abstract: A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported.
CiteXplore: 10843219