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ID: ALA1132881
Journal: Bioorg Med Chem Lett
Title: First pharmacophoric hypothesis for 5-HT7 antagonism.
Authors: López-Rodríguez ML, Porras E, Benhamú B, Ramos JA, Morcillo MJ, Lavandera JL.
Abstract: In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.
CiteXplore: 10843226