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ID: ALA1132891
Journal: Bioorg Med Chem Lett
Title: Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists.
Authors: Tilley J, Kaplan G, Fotouhi N, Wolitzky B, Rowan K.
Abstract: Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide.
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