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ID: ALA1132892
Journal: Bioorg Med Chem Lett
Title: Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists.
Authors: Fotouhi N, Joshi P, Tilley JW, Rowan K, Schwinge V, Wolitzky B.
Abstract: Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependent on ring size and the position of the sulfur atom.
CiteXplore: 10866373