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ID: ALA1132893
Journal: Bioorg Med Chem Lett
Title: The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic.
Authors: Fotouhi N, Joshi P, Fry D, Cook C, Tilley JW, Kaplan G, Hanglow A, Rowan K, Schwinge V, Wolitzky B.
Abstract: The Asp-Pro sequence of the cyclic peptide Ac-HN-Tyr-Cys*-Asp-Pro-Cys*-OH (1) could be replaced with the achiral dipeptide mimetic 1-(2-aminoethyl)cyclpentylcarboxylic acid with retention of potent inhibition of the VCAM-VLA-4 interaction.
CiteXplore: 10866374