Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters.

ID: ALA1132915

Journal: Bioorg Med Chem Lett

Title: Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters.

Authors: Hill CM, Wu F, Cheng TC, DeFrank JJ, Raushel FM.

Abstract: The enzyme OPAA hydrolyzes p-nitrophenyl phosphotriesters bearing substituents at the phosphorus center ranging in size from methyl to phenyl. The enzyme exhibits stereoselectivity toward the hydrolysis of chiral substrates with a preference for the Sp enantiomer.

CiteXplore: 10866401

DOI: 10.1016/s0960-894x(00)00213-4

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