Document Report Card
Basic Information
ID: ALA1133026
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship studies of flavopiridol analogues.
Authors: Murthi KK, Dubay M, McClure C, Brizuela L, Boisclair MD, Worland PJ, Mansuri MM, Pal K.
Abstract: Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.
CiteXplore: 10843211