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ID: ALA1133028
Journal: Bioorg Med Chem Lett
Title: The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues.
Authors: Kuksa VA, Pavlov VA, Lin PK.
Abstract: A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI50 value in the range of 3.9-28.9 microM. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity.
CiteXplore: 10866396