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ID: ALA1133030
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.
Authors: deLong MA, Amburgey J, Taylor C, Wos JA, Soper DL, Wang Y, Hicks R.
Abstract: The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.
CiteXplore: 10915040