Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities.
Basic Information
ID: ALA1133040
Journal: Bioorg Med Chem Lett
Title: Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities.
Authors: Chang LC, Gills JJ, Bhat KP, Luyengi L, Farnsworth NR, Pezzuto JM, Kinghorn AD.
Abstract: Two new cardenolides, (-)-14-hydroxy-3beta-(3-O-methyl-6-deoxy-alpha-L-rhamnosyl)-11a lpha, 12alpha-epoxy-(5beta,14beta,17betaH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3beta-(3-O-methyl-6-deoxy-alpha-L-glucopyranosyl)-11al pha,12alpha-epoxy-(5beta,14beta,17betaH)-card -20(22)-enolide (2), and a known cardenolide, (-)-17beta-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and antiestrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used.
CiteXplore: 11078194
DOI: 10.1016/s0960-894x(00)00477-7
Patent ID: ┄