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ID: ALA1133042

Journal: Bioorg Med Chem Lett

Title: Convergent synthesis of ribonuclease L-active 2',5'-oligoadenylate-peptide nucleic acids.

Authors: Wang Z, Chen L, Bayly SF, Torrence PF.

Abstract: 2-5A was conjugated to N-(2-aminoethyl)-glycyl PNA by periodate oxidization, followed by coupling with amino-derivatized PNA and final cyanoborohydride reduction. An adduct of 2-5A pentamer with tetrameric thymine PNA activated RNase L with the same potency as earlier versions of 2-5A-PNA or 2-5A-DNA.

CiteXplore: 10890163

DOI: 10.1016/s0960-894x(00)00240-7