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ID: ALA1133065
Journal: Bioorg Med Chem Lett
Title: Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide.
Authors: Blagbrough IS, Geall AJ, David SA.
Abstract: Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.
CiteXplore: 10987426