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ID: ALA1133072
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activity of 1beta-methyl-2-[5'-isoxazoloethenylpyrrolidin-3'-ylthio]carbapenems.
Authors: Kim DJ, Seo KJ, Lee KS, Shin KJ, Yoo KH, Kim DC, Park SW.
Abstract: A new series of 1beta-methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability.
CiteXplore: 11133095