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ID: ALA1133078
Journal: Bioorg Med Chem Lett
Title: Isoxazolines and isoxazoles as factor Xa inhibitors.
Authors: Pruitt JR, Pinto DJ, Estrella MJ, Bostrom LL, Knabb RM, Wong PC, Wright MR, Wexler RR.
Abstract: 3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.
CiteXplore: 10782664