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ID: ALA1133080
Journal: Bioorg Med Chem Lett
Title: Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Authors: Missbach M, Altmann E, Widler L, Susa M, Buchdunger E, Mett H, Meyer T, Green J.
Abstract: 5,7-Diphenyl-pyrrolo[2,3d]pyrimidines represent a new class of highly potent inhibitors of the tyrosine kinase c-Src (IC50 < 50 nM) with specificity against a panel of different tyrosine kinases. The substitution pattern on the two phenyl rings determines potency and specificity and provides a means to modulate cellular activity.
CiteXplore: 10853665