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ID: ALA1133128
Journal: Bioorg Med Chem Lett
Title: Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules.
Authors: Wang W, Préville P, Morin N, Mounir S, Cai W, Siddiqui MA.
Abstract: An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.
CiteXplore: 10866369