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ID: ALA1133153
Journal: Bioorg Med Chem Lett
Title: Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.
Authors: Wells G, Bradshaw TD, Diana P, Seaton A, Shi DF, Westwell AD, Stevens MF.
Abstract: The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
CiteXplore: 10743960