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ID: ALA1133216
Journal: Bioorg Med Chem Lett
Title: Synthesis and structure-activity relationships of novel fungal chitin synthase inhibitors.
Authors: Masubuchi K, Taniguchi M, Umeda I, Hattori K, Suda H, Kohchi Y, Isshiki Y, Sakai T, Kohchi M, Shirai M, Okabe H, Sudoh M, Yamazaki T, Shimma N.
Abstract: A novel Candida albicans chitin synthase 1 (CaChs1) inhibitor, RO-41-0986 (1) was discovered by random screening. Systematic modification led to the identification of a highly potent CaChs1 inhibitor, RO-09-3024 (2), having strong antifungal activity against Candida spp. in vitro.
CiteXplore: 10888332