Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.

ID: ALA1133305

Journal: Bioorg Med Chem Lett

Title: Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.

Authors: Einsiedel J, Thomas C, Hübner H, Gmeiner P.

Abstract: Conformationally restricted benzamide bioisosteres were investigated when the aminomethylpyrrolidine derivative 4o proved D3 as well as D4 binding properties which were comparable to those of the atypical neuroleptics sulpiride and clozapine, respectively.

CiteXplore: 10987445

DOI: 10.1016/s0960-894x(00)00405-4

Patent ID: ┄