Document Report Card

Basic Information

ID: ALA1133323

Journal: Bioorg Med Chem Lett

Title: Antitumor agents. Part 202: novel 2'-amino chalcones: design, synthesis and biological evaluation.

Authors: Xia Y, Yang ZY, Xia P, Bastow KF, Nakanishi Y, Lee KH.

Abstract: New 4',5',2,3,4-substituted 2'-amino chalcones were synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines. Several compounds displayed significant cytotoxicity. The most promising lead molecule (10) also had high activity toward multi-drug resistant KB-VIN, and ovarian 1A9 cell lines. 2'-Amino chalcones demonstrated significantly increased antitumor activity compared with the corresponding chalcones, while, the epoxide derivatives generally showed greatly reduced activity.

CiteXplore: 10782667

DOI: 10.1016/s0960-894x(00)00072-x