Document Report Card
Basic Information
ID: ALA1133331
Journal: Bioorg Med Chem Lett
Title: Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.
Authors: Tamura SY, Levy OE, Uong TH, Reiner JE, Goldman EA, Ho JZ, Cohen CR, Bergum PW, Nutt RF, Brunck TK, Semple JE.
Abstract: A novel series of rigid P3-guanylpiperidine peptide mimics 3-14 was designed as potential factor Xa and prothrombinase inhibitors. Incorporation into a P2-gly-P1-argininal motif led to highly potent and selective inhibitors. The synthesis and biological activities of these derivatives are reported herein.
CiteXplore: 10782677