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ID: ALA1133340

Journal: Bioorg Med Chem Lett

Title: Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors.

Authors: Lübbers T, Angehrn P, Gmünder H, Herzig S, Kulhanek J.

Abstract: We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity.

CiteXplore: 10782694

DOI: 10.1016/s0960-894x(00)00109-8