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ID: ALA1133346

Journal: Bioorg Med Chem Lett

Title: The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors.

Authors: Buynak JD, Doppalapudi VR, Adam G.

Abstract: A series of 3-substituted-7-(alkylidene)cephaloporin sulfones were prepared and evaluated as inhibitors of representative class A and class C serine beta-lactamase. Appropriate substituents resulted in a 1000-fold improvement in the inhibition of the class A enzymes and a simultaneous 20-fold improvement in the inhibition of class C. These new compounds have achieved the goal of creating broad scale inhibitors in the cephalosporin series.

CiteXplore: 10853646

DOI: 10.1016/s0960-894x(00)00098-6