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ID: ALA1133348
Journal: Bioorg Med Chem Lett
Title: Quinonic derivatives active against a virulent strain of Toxoplasma gondii. Synthesis of 2-methylfuro[2,3-g]- and [3,2-g]isoquinolinetriones.
Authors: Nebois P, Sarciron ME, Bibal B, Bouammali B, Cherkaoui O, Pautet F, Pétavy AF, Walchshofer N, Fillion H.
Abstract: 2-methylfuro[2,3-g]isoquinoline-4,7,9-trione (4) and 2-methylfuro[3,2-g]isoquinoline-4,6,9-trione (5) were prepared regiospecifically from 2-azadiene 9 and bromobenzofuran-4,7-diones 1 or 11. The activity of these two compounds and some other quinonic derivatives was evaluated in vitro against a virulent strain of Toxoplasma gondii. Compounds 4 and 7 were found to be as active as pyrimethamine.
CiteXplore: 10853649