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ID: ALA1133361
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors.
Authors: Tamura SY, Weinhouse MI, Roberts CA, Goldman EA, Masukawa K, Anderson SM, Cohen CR, Bradbury AE, Bernardino VT, Dixon SA, Ma MG, Nolan TG, Brunck TK.
Abstract: Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems.
CiteXplore: 10853674