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ID: ALA1133367
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.
Authors: Hayashi Y, Iijima K, Katada J, Kiso Y.
Abstract: Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.
CiteXplore: 10698435