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ID: ALA1133376
Journal: Bioorg Med Chem Lett
Title: Recognition and inhibition of HIV integrase by a novel dinucleotide.
Authors: Taktakishvili M, Neamati N, Pommier Y, Nair V.
Abstract: The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually novel dinucleotide, pIsodApdC, which is a potent inhibitor of this key viral enzyme.
CiteXplore: 10698446