Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Basic Information
ID: ALA1133378
Journal: Bioorg Med Chem Lett
Title: Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Authors: Kar AK, Braun PD, Wandless TJ.
Abstract: Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines.
CiteXplore: 10698449
DOI: 10.1016/s0960-894x(99)00667-8
Patent ID: ┄
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